FORMULATION OF NANOEMULGEL CONTAINING EXTRACT OF IMPATIENTS BALSAMINA L. AND ITS ANTIBACTERIAL ACTIVITY

Objective: This study aimed to optimize the nanoemulgel formulation for balsam leaves (Impatients balsamina L.) extract and determine its antibacterial activity. Methods: Balsam were extracted using maceration method ethanol. The nanoemulsion of ethanol was prepared with various oil, surfactants, co-surfactant concentrations. Characterization conducted on formed, including transmittance, droplet size, polydispersity index, zeta potential. chosen formula then transformed into a gel preparation gelling agent concentrations, i.e., Carbopol 940 chitosan, optimized Design-Expert v13 software simplex lattice design method. Results: discovered optimum desirability value 0.859. ratio chitosan 1.38% 0.12%w/w, respectively, an activity inhibition zone against S. epidermidis 22±2 mm in diameter. Conclusion: observed responses closely matched predicted values provided by optimization has potential develop as dosage form.